Lower doses (5 mg) resemble Adderall or MDMA and don’t produce strong visuals. Most of them were invented around the same time by Alexander Shulgin and documented in one of his books PiHKAL. 2C-B can also be vaporized — but this isn’t a common way of using it, and the long-term health effects of taking 2C-B this way aren’t well understood. Many compounds will change when heated like this, and the byproducts of vaporized 2C-B are not well understood.
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- The decline in the gun death rate since 2021 is mostly due to a decrease in the rate of gun murders.
- Most psychedelics work by activating the 5-HT2A serotonin receptors.
- The CDC’s statistics are based on information from official death certificates, while the FBI’s figures are based on information voluntarily submitted by thousands of police departments around the country.
- It’s not uncommon for people using 2C-B to come to some sort of “realization” about their life.
- Most people take 2C-B orally and experience a burning sensation when ingesting the drug.
How To Get the Most out of Taking MDMA as a CoupleTaking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship. Microdosing Ketamine & Common Dosages ExplainedMicrodosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine. Differentiating DMT and Near-Death ExperiencesSome say there are similarities between a DMT trip and death. Read our guide on differentiating DMT and near-death experiences to find out. New Johns Hopkins StudyJohns Hopkins University School of Medicines has just published a new study on psychoactive effects of psilocybin.
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Combining 2C drugs with other psychedelics can lead to unpredictable effects and may intensify the experience beyond what is expected or desired. 2C compounds share some similarities with other stimulants, like amphetamines or cocaine, which, if combined, can increase the risk of cardiovascular issues, such as elevated heart rate and blood pressure. Selective Serotonin Reuptake Inhibitors (SSRIs) and Monoamine Oxidase Inhibitors (MAOIs) can interact with serotonergic psychedelics. Combining them can lead to serotonin syndrome, a potentially life-threatening condition. Taking MDMA substitutes or untested MDMA doses is not recommended due to the rising rate what is 2c-b of accidental methamphetamine dosing in cases where pills are sold as pure MDMA.
The number of gun murders fell from a record 20,958 in 2021 to 17,927 in 2023, a 14% decrease. More than half of all suicides in 2023 – 27,300 out of 49,316, or 55% – also involved a gun. That was one of the highest percentages since 2000, when 57% of suicides involved a firearm.
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. As with other serotonergic psychedelic, 2C-B is considered to be non-addictive with a low potential for abuse. It is strongly recommended that one use harm reduction practices when using this substance.
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It’s important to note, the doses mentioned above were all ingested orally, which is the most popular way to take 2C-B. Folks report either swallowing a pill, weighing out their dose and mixing it with water, or “bombing” their dose by putting it in a rolling paper or piece of toilet paper, and swallowing it all like a pill. But nasal ingestion is also done, although many people warn that it is extremely painful—more so than with other substances. However, if you do choose to ingest nasally, doses should be significantly smaller because it comes on faster and stronger, and will also be shorter-lasting. Therefore, like with all psychedelics, it’s best to take a low or moderate dose for your first experience, and if you find you want to go deeper, experiment with slightly higher doses in subsequent trips.
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- Initially introduced as a psychotherapeutic drug in the 1970s, it became known as an aphrodisiac.
- The legal use of 2C-B came to a stop in 1995, when the DEA classed it as a Schedule I substance in the US.
- While 2C-B may not cause the classic signs of physical addiction, you can develop tolerance.
- The drug’s creator, Alexander Shulgin, suggested 2C-B was a good follow-up treatment in psychotherapy after MDMA.
Similar to cocaine, 2C-B can induce chills, nausea, muscle spasms, confusion, insomnia/restlessness, visual effects, overwhelming emotions, paranoia, and decreased appetite. It seems so for healthy individuals, and there have been no deaths linked to its use. But as Nichols points out, “until there are formal preclinical toxicology studies, however, I think no one can be sure it is completely safe.” If a lethal dose exists, it’s still unknown.
Unlike on MDMA, sexual arousal can be maintained throughout the 2C-B experience. 2C-B is a potentially illegal substance, and we do not encourage or condone the use of this substance where it is against the law. However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use the substance. So far, very little information is available regarding the addiction potential of 2C-B and other drugs in this class.
How Does 2C-B Impact Mental Health?
This family of chemical compounds are considered Schedule I drugs, the most tightly controlled and generally illegal class. This includes psilocybin (aka Magic Mushrooms), Methylenedioxymethamphetamine (MDMA), Lysergic acid diethylamide (LSD), N,N-Dimethyltryptamine (DMT), Ayahuasca, Ibogaine, Peyote, 2C-B, Cannabis, and others. Ketamine is also controlled under the same act and listed as a Schedule III drug. The world knows 2C-B as a psychedelic drug which was first manufactured in 1974 to support therapy. Belonging to the class of drugs called 2C drugs, it has many structural similarities with MDMA and Ecstasy. When MDMA was declared illegal in 1985, the prevalence and use of 2C-B suddenly increased, especially on the streets.
Some studies suggest 2C-B activates another serotonin receptor called 5-HT2C — which also produces hallucinogenic effects 4. Both 2C-B and mescaline are thought of as being “gentle” when compared to other psychedelics and the visuals are very similar between the two. All 2C- substances contain methoxy groups on the 2 and 5 positions of a benzene ring of its chemical structure.
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If taken orally, the effects of 2CB will take about 45 minutes to an hour to come on and will last from 4- 6 hours (dose-dependent). Evan Lewis-Healey is a Cognitive Neuroscience researcher and science writer from the UK. He studied a Master’s in Brain and Cognitive Sciences at the University of Amsterdam (UvA), where he spent his time researching and writing about the neuroscience of psychedelics and meditation.
Many people believe that 2C-B has a low addiction potential like other hallucinogenic drugs. This is because most hallucinogenic drugs act in the serotogenic pathways in the brain. Similarly, no convincing evidence proves 2C-B to induce tolerance in users.
Third Wave’s Ultimate Guide to Sourcing Psychedelic Medicines provides tips and resources to obtain psychedelics in most countries–from trusted sellers. It is illegal in the United States, Canada, the European Union (except the Czech Republic and Portugal), Australia, and more. In his book PiHKAL (Phenethylamines I Have Known And Loved), the legendary psychopharmacologist and author Alexander “Sasha” Shulgin named 2C-B one of the six most important phenethylamines for healing trauma.
By the early Nineties, Americans had become the world’s largest consumer of Nexus, often buying packs at sex and head shops and eating four or five pills (the equivalent of 20–25 mg) for its psychedelic effects. By 1995, 2C-B was criminalized and placed in Schedule 1 of the Controlled Substances Act, and the US successfully urged other countries to do the same. Like with most psychedelic drugs, quitting 2C-B cold turkey can be challenging. Most experienced users recommend reducing dosages to wean off the drug. When stopping 2C-B use, using a milligram scale to weigh the dosage is best.











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